In silico modelling and analysis of the electrical and mechanical properties of in vitro cardiac cultures with different fiber architectures
Contributo in Atti di convegno
Data di Pubblicazione:
2015
Citazione:
In silico modelling and analysis of the electrical and mechanical properties of in vitro cardiac cultures with different fiber architectures / F. Del Bianco, P. Colli Franzone, S. Scacchi, L. Fassina - In: Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)[s.l] : IEEE, 2015. - ISBN 9781424492718. - pp. 38-42 (( Intervento presentato al 37. convegno Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC tenutosi a Milano nel 2015 [10.1109/EMBC.2015.7318295].
Abstract:
Today, in vitro cardiac cultures are widely exploited to investigate several aspects of the electromechanical behavior of the cardiac tissue. Thus, new forecasts may derive from modelling their properties. In particular, in this paper, we focus on the fiber architecture of cultures, i.e. on the way cellular sarcomeres are locally oriented, when they are designed to be cardiac patches. We employ a three-dimensional model to simulate the bioelectrical activity and the biomechanics of a multilayered culture made of ventricular cells and with four possible architectures consisting of: i) random fibers in all cells; ii) randomly rotating fibers among layers; iii) structurally rotating fibers from the bottom layer to the top one; iv) parallel fibers among layers. Our results suggest that the best configuration for a patch may be the architecture with structurally rotating fibers, which is the one that most approaches the anisotropic structure of the in vivo heart, thanks to its better electrical and mechanical performances.
Tipologia IRIS:
03 - Contributo in volume
Keywords:
muscle; heart
Elenco autori:
F. Del Bianco, P. Colli Franzone, S. Scacchi, L. Fassina
Link alla scheda completa:
Titolo del libro:
Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)