Creep-resistant dextran-based polyurethane foam as a candidate scaffold for bone tissue engineering : synthesis, chemico-physical characterization, andin vitroandin vivobiocompatibility
Articolo
Data di Pubblicazione:
2016
Citazione:
Creep-resistant dextran-based polyurethane foam as a candidate scaffold for bone tissue engineering : synthesis, chemico-physical characterization, andin vitroandin vivobiocompatibility / I. Gerges, M. Tamplenizza, S. Lopa, C. Recordati, F. Martello, A. Tocchio, L. Ricotti, C. Arrigoni, P. Milani, M. Moretti, C. Lenardi. - In: INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS. - ISSN 0091-4037. - 65:14(2016), pp. 729-740. [10.1080/00914037.2016.1163565]
Abstract:
A highly crosslinked composite dextran-based scaffold (named DexFoam) was tailored to overcome
specific deficiencies of polymeric and ceramic bone scaffolds and to guarantee a bone-mimicking
microenvironment for the proliferation of human mesenchymal stem cells
in vitro
. The creep resistance for up to 90% compressive stain, the capability to regain the original shape after deformation, and the
good thermal stability in both physiological and “body limit” conditions make DexFoam a valid
alternative to the currently available bone scaffolds. Histopathological evaluation for host reaction and
tissue colonization of DexFoam scaffold, implanted subcutaneously in mice, demonstrated its
in vivo biocompatibility and biodegradability
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Bone graft substitute; composite scaffolds; dextran; polyurethane; regenerative medicine; tissue engineering
Elenco autori:
I. Gerges, M. Tamplenizza, S. Lopa, C. Recordati, F. Martello, A. Tocchio, L. Ricotti, C. Arrigoni, P. Milani, M. Moretti, C. Lenardi
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