Effect of activin A on tumor necrosis factor-alpha/intercellular adhesion molecule-1 pathway in endometrial stromal cells
Articolo
Data di Pubblicazione:
2005
Citazione:
Effect of activin A on tumor necrosis factor-alpha/intercellular adhesion molecule-1 pathway in endometrial stromal cells / S. Mangioni, P. Viganò, P. Florio, O. Borghi, M. Vignali, F. Petraglia, A.M. Di Blasio. - In: EUROPEAN JOURNAL OF OBSTETRICS, GYNECOLOGY, AND REPRODUCTIVE BIOLOGY. - ISSN 0301-2115. - 123:2(2005 Dec), pp. 218-223. [10.1016/j.ejogrb.2005.03.017]
Abstract:
Objective[s]: Activin A and inhibin A are growth factors expressed by human endometrium involved in the control of endometrial functions.
In the present study we investigated the effects of activin A and inhibin A in modulating the tumor necrosis factor (TNF)-a/intercellular adhesion molecule (ICAM)-1 system in cultured human endometrial stromal cells.
Study design: Endometrial samples were obtained from 34 reproductive age women undergoing laparoscopy for benign ovarian cysts or infertility. Endometrial stromal cells were cultured and soluble ICAM-1 and TNF-a were measured in cell-free supernatants following treatment with or without activin A or inhibin A. Cell surface ICAM-1 was assayed by flow cytometry by staining endometrial cells with specific monoclonal antibodies.
Results: Activin A and inhibin A did not influence either the expression of cell surface ICAM-1 or soluble ICAM-1 shedding by cultured endometrial cells. On the other hand, TNF-a secretion significantly increased in presence of activin A but not of inhibin A.
Conclusions: Since TNF-a modulates several endometrial processes such as menstruation, proliferation, apoptosis, implantation and decidualization, an effect of activin A in the physiological control of endometrium is further supported by the present data.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Activin A; Endometrium; ICAM-1; TNF-α
Elenco autori:
S. Mangioni, P. Viganò, P. Florio, O. Borghi, M. Vignali, F. Petraglia, A.M. Di Blasio
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