Gene promoter methylation and expression of Pin1 differ between patients with frontotemporal dementia and Alzheimer's disease
Articolo
Data di Pubblicazione:
2016
Citazione:
Gene promoter methylation and expression of Pin1 differ between patients with frontotemporal dementia and Alzheimer's disease / E. Ferri, B. Arosio, C. D'Addario, D. Galimberti, C. Gussago, M. Pucci, M. Casati, C. Fenoglio, C. Abbate, P.D. Rossi, E. Scarpini, M. Maccarrone, D. Mari. - In: JOURNAL OF THE NEUROLOGICAL SCIENCES. - ISSN 0022-510X. - 362(2016 Mar 15), pp. 283-286.
Abstract:
Frontotemporal Dementia (FTD) and Alzheimer's Disease (AD) share the accumulation of fibrillar aggregates of misfolded proteins. To better understand these neurodegenerative diseases and identify biomarkers in easily accessible cells, we investigated DNA methylation at Pin1 gene promoter and its expression in peripheral blood mononuclear cells of FTD patients. We found a lower gene expression of Pin1 with a higher DNA methylation in three CpG sites at Pin1 gene promoter analysed in FTD subjects, in contrast to a higher gene expression with a lower methylation in AD subjects and controls. These data suggest an important and distinct involvement of Pin1 in these two types of dementia.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Alzheimer's disease; Frontotemporal dementia; Methylation; Neurodegeneration; Peripheral marker; Pin1
Elenco autori:
E. Ferri, B. Arosio, C. D'Addario, D. Galimberti, C. Gussago, M. Pucci, M. Casati, C. Fenoglio, C. Abbate, P.D. Rossi, E. Scarpini, M. Maccarrone, D. Mari
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