Penetration of amphotericin B in human lung tissue after single liposomal amphotericin B (AmBisome) infusion
Articolo
Data di Pubblicazione:
2005
Citazione:
Penetration of amphotericin B in human lung tissue after single liposomal amphotericin B (AmBisome) infusion / G. Demartini, C. Lequaglie, P. P. Brega Massone, F. Scaglione, F. Fraschini. - In: JOURNAL OF CHEMOTHERAPY. - ISSN 1120-009X. - 17:1(2005 Feb), pp. 82-85.
Abstract:
The distribution of amphotericin B in lung tissue was studied in 18 patients with primary or secondary lung cancer who underwent thoracotomy and pulmonary resection. At different times before surgery the patients were treated with liposomal amphotericin B 1.5 mg/kg by i.v. infusion over 1h. Blood and lung tissue samples were collected during surgery (one subjects for each collecting time) and assayed for amphotericin B levels by HPLC. Due to surgical requirements, it was possible to obtain data from the 10th to the 25th h after the end of infusion. Plasma amphotericin B concentrations progressively decreased from 3.4 mcg/ml at the 10th h to 1 mcg/ml at the 25th h after the end of intravenous infusion. In lung tissue samples the lowest amphotericin B concentration (about 1 mcg/g) was observed at the 10th h, then a progressive increase was observed with the highest value (2.5 mcg/g) determined at the 25th h.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Humans; Liposomal amphotericin B; Lung tissue distribution
Elenco autori:
G. Demartini, C. Lequaglie, P. P. Brega Massone, F. Scaglione, F. Fraschini
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