Data di Pubblicazione:
2016
Citazione:
Recommendations for pediatric tuberculosis vaccination in Italy / C. Montagnani, S. Esposito, L. Galli, E. Chiappini, N. Principi, M. de Martino. - In: HUMAN VACCINES & IMMUNOTHERAPEUTICS. - ISSN 2164-5515. - 12:3(2016), pp. 644-650. [10.1080/21645515.2015.1106657]
Abstract:
Bacillus Calmette-Guérin (BCG) vaccine is still the only vaccine approved for the prevention of tuberculosis (TB), and is widely used in highly endemic countries, where all newborns receive a single intradermal dose immediately after birth; however, the recommendations concerning its use in Europe vary widely from country to country. This document describes the recommendations of a group of Italian scientific societies concerning its pediatric use in Italy, the persistence of the protection it provides, its safety, its interference with tuberculin skin test (TST) responses, and the children who should be vaccinated. The experts conclude that BCG vaccination provides a good level of protection against tuberculous meningitis and disseminated forms, and a fair level of protection against pulmonary disease; the protective effective lasts at least ten years, and revaccination offers no advantages over a single administration. The vaccine is safe in immunocompetent subjects, and affects the response to a TST for at least six years. On the basis of these observations, we recommend its use in Italy in all TST-negative immunocompetent newborns and breastfeeding infants aged <6 months, and all TST-negative children aged between six months and five years who come from highly epidemic areas, or whose parents come from highly endemic areas, or who have been in contact with a family member with active TB without contracting the disease themselves.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
BCG; children; prevention; tuberculosis; vaccination; vaccine
Elenco autori:
C. Montagnani, S. Esposito, L. Galli, E. Chiappini, N. Principi, M. de Martino
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