Can we transfer pharmacokinetics/pharmacodynamics of antimicrobials into clinical practice?
Articolo
Data di Pubblicazione:
2015
Citazione:
Can we transfer pharmacokinetics/pharmacodynamics of antimicrobials into clinical practice? / F. Scaglione. - In: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS. - ISSN 0924-8579. - 46:suppl. 1(2015 Dec), pp. S40-S42. [10.1016/j.ijantimicag.2015.10.009]
Abstract:
In critically ill patients there is extensive evidence of subtherapeutic antibiotic exposure from standard doses across different antibiotic classes. This can be a direct consequence of pharmacokinetic alterations emanating from the complex pathophysiological processes associated with severe infection. Therapeutic drug monitoring (TDM) is being increasingly used for antibiotic dose optimisation in an attempt to improve the attainment of pharmacokinetic/pharmacodynamic (PK/PD) targets and the outcomes of severe infection in critically ill patients. In clinical practice, it is necessary to reduce the number of blood samples collected from the patient to a minimum because of the cost (personnel, devises and analysis). TDM to calculate PK/PD indices is easily feasible only when a single blood sample is adequate to perform the analysis.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Critical illness; Dose optimisation; Pharmacodynamics; Pharmacokinetics; Therapeutic drug monitoring; Microbiology (medical); Infectious Diseases; Pharmacology (medical)
Elenco autori:
F. Scaglione
Link alla scheda completa: