Norethindrone acetate or dienogest for the treatment of symptomatic endometriosis : a before and after study
Articolo
Data di Pubblicazione:
2016
Citazione:
Norethindrone acetate or dienogest for the treatment of symptomatic endometriosis : a before and after study / P. Vercellini, B. Bracco, P. Mosconi, A. Roberto, D. Alberico, D. Dhouha, E. Somigliana. - In: FERTILITY AND STERILITY. - ISSN 0015-0282. - 105:3(2016 Mar), pp. 734-743.
Abstract:
OBJECTIVE:
To assess the proportion of patients satisfied with their treatment before and after a systematic change from norethindrone acetate to dienogest as the first-line progestin for symptomatic endometriosis.
DESIGN:
Before and after study.
SETTING:
Academic department.
PATIENT(S):
The last 90 new consecutive endometriosis patients in whom norethindrone acetate was used, and the first 90 new consecutive endometriosis patients in whom dienogest was used.
INTERVENTION(S):
Norethindrone acetate at the oral dose of 2.5 mg once a day until June 6, 2013, then dienogest at the oral dose of 2 mg once a day thereafter.
MAIN OUTCOME MEASURE(S):
Degree of satisfaction with treatment after 6 months of progestin therapy and assessment of any variations in pain symptoms, psychological status, sexual function, or health-related quality of life associated with the introduction of dienogest.
RESULT(S):
The proportion of satisfied plus very satisfied women after 6 months of treatment was 71% in the "before" period (norethindrone acetate) and 72% in the "after" period (dienogest). The implementation of dienogest was not associated with statistically significant ameliorations in overall pain relief, psychological status, sexual functioning, or health-related quality of life. Treatment was well tolerated by 58% of norethindrone acetate users compared with 80% of dienogest users. After dienogest implementation, the absolute risk reduction in the occurrence of any side effect was 13.9% (95% confidence interval, 0.8%-28.6%).
CONCLUSION(S):
Considering the large difference in the cost of the two drugs, dienogest should be suggested selectively in women who do not tolerate norethindrone acetate.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
before and after study; dienogest; endometriosis; norethisterone acetate; pelvic pain
Elenco autori:
P. Vercellini, B. Bracco, P. Mosconi, A. Roberto, D. Alberico, D. Dhouha, E. Somigliana
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