Decreased Bdnf expression and reduced social behavior in periadolescent rats following prenatal stress
Articolo
Data di Pubblicazione:
2015
Citazione:
Decreased Bdnf expression and reduced social behavior in periadolescent rats following prenatal stress / A. Berry, P. Panetta, A. Luoni, V. Bellisario, S. Capoccia, M.A. Riva, F. Cirulli. - In: DEVELOPMENTAL PSYCHOBIOLOGY. - ISSN 0012-1630. - 57:3(2015 Apr), pp. 365-373. [10.1002/dev.21297]
Abstract:
Prenatal stress (PNS) is a risk factor for the development of neuropsychiatric disorders. This study was aimed at assessing, in a rodent model, changes in gene expression profiles and behavioral output as a result of PNS, during periadolescence, a critical developmental period for the onset of psychopathology. Social behavior was studied in a standardized social interaction paradigm and the expression of Brain-Derived Neurotrophic Factor (Bdnf), a marker of neuronal plasticity, and of inhibitory and excitatory mechanisms (Na+-K+-2Cl-and K+-Cl- cotransporters ratio, NKCC1/KCC2) was analyzed. Results indicate that PNS reduced Bdnf transcripts while increasing the NKCC1/KCC2 ratio, primarily in the hippocampus. In the prefrontal cortex, changes in Bdnf were found to be gender-dependent. These effects were accompanied by reduced levels of affiliative and investigative social behaviors. Interestingly, interaction with non-stressed subjects was able to improve sociality in PNS rats suggesting that the social environment could be exploited for therapeutic intervention.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Bdnf; Gene expression; Hippocampus; Periadolescence; Prefrontal cortex; Prenatal stress; Rats; Social behavior; Developmental Biology; Behavioral Neuroscience; Developmental Neuroscience; Developmental and Educational Psychology
Elenco autori:
A. Berry, P. Panetta, A. Luoni, V. Bellisario, S. Capoccia, M.A. Riva, F. Cirulli
Link alla scheda completa: