Data di Pubblicazione:
2015
Citazione:
Peptidyl-prolyl isomerases : A full cast of critical actors in cardiovascular diseases / G.L. Perrucci, A. Gowran, M. Zanobini, M.C. Capogrossi, G. Pompilio, P. Nigro. - In: CARDIOVASCULAR RESEARCH. - ISSN 0008-6363. - 106:3(2015 Mar 06), pp. 353-364. [10.1093/cvr/cvv096]
Abstract:
Peptidyl-prolyl cis-trans-isomerases are a highly conserved family of immunophilins. The three peptidyl-prolyl cis-trans-isomerase subfamilies are cyclophilins, FK-506-binding proteins, and parvulins. Peptidyl-prolyl cis-trans-isomerases are expressed in multiple human tissues and regulate different cellular functions, e.g. calcium handling, protein folding, and gene expression. Moreover, these subfamilies have been shown to be consistently involved in several cardiac and vascular diseases including heart failure, arrhythmias, vascular stenosis, endothelial dysfunction, atherosclerosis, and hypertension. This review provides a concise description of the peptidyl-prolyl cis-trans-isomerases and presents an incisive selection of studies focused on their relationship with cardiovascular diseases.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Cardiovascular disease; Cyclophilins; FKBPs; Parvulins; Cardiology and Cardiovascular Medicine; Physiology (medical); Physiology
Elenco autori:
G.L. Perrucci, A. Gowran, M. Zanobini, M.C. Capogrossi, G. Pompilio, P. Nigro
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