Data di Pubblicazione:
2014
Citazione:
Reference intervals for acetylated fetal hemoglobin in healthy newborns / R. Paleari, I. Mutta, G. Musolino, A. Salvatoni, M. Agosti, G. Francescato, A. Mosca. - In: THALASSEMIA REPORTS. - ISSN 2039-4365. - 4:2120(2014), pp. 52-54. [10.4081/thal.2014.s1.2120]
Abstract:
The acetylated fetal hemoglobin (AcHbF)
derives from an enzyme-mediated post-translational
modification occurring on the N-terminal
glycine residues of g-chains. At present,
no established data are available on reference
intervals for AcHbF in newborns. A total of 92
healthy infants, with gestational age between
37 and 41 weeks were selected for the establishment
of AcHbF reference intervals. Blood
samples were collected by heel pricking, when
collecting routine neonatal screening, and the
hemoglobin pattern was analyzed by high-performance
liquid chromatography. AcHbF
results were then normalized for HbF content
in order to account for differences in hemoglobin
switch. No difference was found in AcHbF
values between genders (P=0.858). AcHbF
results were as follow: 12.8±0.8% (mean±standard
deviation), reference interval: 11.3-14.3%.
This finding could facilitate further studies
aimed to assess the possible use of AcHbF, for
instance as a possible fetal metabolic biomarker
during pregnancy.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
fetal hemoglobin; HbA1c; neonatal screening
Elenco autori:
R. Paleari, I. Mutta, G. Musolino, A. Salvatoni, M. Agosti, G. Francescato, A. Mosca
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