Data di Pubblicazione:
1975
Citazione:
Adaptation of the mitochondrial systems of Rhodotorula gracilis to low oxygen pressure / M. Cocucci, G. Rossi, T. Vandoni. - In: CELL DIFFERENTIATION. - ISSN 0045-6039. - 4:3(1975), pp. 155-165. [10.1016/0045-6039(75)90037-8]
Abstract:
The obligate aerobic yeast, Rhodotorula gracilis, was grown in a liquid minimal medium at 1 mm Hg partial pressure of oxygen, conditions under which growth (measured as the increase in total protein) is reduced to 30% of the maximum rate. A significant increase in the ratio between mitochondrial oxidative enzymes and total protein occurs rapidly under these conditions. A concurrent increase in the ratio area of mitochondria/area of cytoplasm was also observed. The relative increase in mitochondrial enzymes, oxidase activities and mitochondrial membranes is due to the inhibition affecting the increase in cytoplasmic structures more significantly than the increase in mitochondrial structures at low pO2. The difference between mitochondrial and cytoplasmic syntheses cannot be ascribed to changes in the availability of ATP but it might rest with some other oxygen-utilising process (pyrimidine redox coenzymes, synthesis of sterols).
The experimental conditions studied appear to offer a valuable tool for the investigation of the relationships between mitochondrial and cytoplasmic structures.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
M. Cocucci, G. Rossi, T. Vandoni
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