Investigation of Functionalized Poly(N,N-dimethylacrylamide)-block-polystyrene Nanoparticles As Novel Drug Delivery System to Overcome the Blood-Brain Barrier In Vitro
Articolo
Data di Pubblicazione:
2015
Citazione:
Investigation of Functionalized Poly(N,N-dimethylacrylamide)-block-polystyrene Nanoparticles As Novel Drug Delivery System to Overcome the Blood-Brain Barrier In Vitro / M. Gregori, D. Bertani, E. Cazzaniga, A. Orlando, M. Mauri, A. Bianchi, F. Re, S. Sesana, S. Minniti, M. Francolini, A. Cagnotto, M. Salmona, L. Nardo, D. Salerno, F. Mantegazza, M. Masserini, R. Simonutti. - In: MACROMOLECULAR BIOSCIENCE. - ISSN 1616-5187. - 15:12(2015 Dec), pp. 1687-1697. [10.1002/mabi.201500172]
Abstract:
In the search of new drug delivery carriers for the brain, self-assembled nanoparticles (NP) were prepared from poly(N,N-dimethylacrylamide)-block-polystyrene polymer. NP displayed biocompatibility on cultured endothelial cells, macrophages and differentiated SH-SY5Y neuronal-like cells. The surface-functionalization of NP with a modified fragment of human Apolipoprotein E (mApoE) enhanced the uptake of NP by cultured human brain capillary endothelial cells, as assessed by confocal microscopy, and their permeability through a Transwell Blood Brain Barrier model made with the same cells, as assessed by fluorescence. Finally, mApoE-NP embedding doxorubicin displayed an enhanced release of drug at low pH, suggesting the potential use of these NP for the treatment of brain tumors.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
blood-brain barrier; controlled drug release; copolymers; drug delivery; nanoparticles; biotechnology; bioengineering; biomaterials; polymers and plastics; materials chemistry2506 metals and alloys
Elenco autori:
M. Gregori, D. Bertani, E. Cazzaniga, A. Orlando, M. Mauri, A. Bianchi, F. Re, S. Sesana, S. Minniti, M. Francolini, A. Cagnotto, M. Salmona, L. Nardo, D. Salerno, F. Mantegazza, M. Masserini, R. Simonutti
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