Data di Pubblicazione:
2001
Citazione:
Anti-neuronal nicotinic receptor antibodies in MG patients with thymoma / C. Gotti, M. Moretti, R. Mantegazza, D.M.M. Fornasari, T. Tsouloufis, F. Clementi. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - 113:1(2001 Feb), pp. 142-145.
Abstract:
We tested 24 MG patients with thymoma (11 invasive) for the presence of anti-neuronal nicotinic receptor subtype antibodies and found that none had antibodies against the alpha7-containing subtype, and only one (with invasive thymoma) had antibodies directed against the alpha3-containing subtype. In this patient, the anti-alpha3 antibodies recognized the extracellular part of the alpha3 subunit. They developed later than the anti-alpha1 muscle antibodies, with their titer increasing during the illness, while that of the anti-alpha1 muscle antibody decreased. Our data suggest that there is no correlation between the presence of anti-alpha3 antibodies and thymoma.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Neuronal nicotinic receptor subtypes ; Thymoma ; Antibodies ; Myasthenia gravis
Elenco autori:
C. Gotti, M. Moretti, R. Mantegazza, D.M.M. Fornasari, T. Tsouloufis, F. Clementi
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