Urinary uric acid to creatinine ratio and lactate to creatinine ratio in healthy and pathologic newborn foals
Abstract
Data di Pubblicazione:
2013
Citazione:
Urinary uric acid to creatinine ratio and lactate to creatinine ratio in healthy and pathologic newborn foals / C. Castagnetti, S. Panzani, P. Scarpa, C. Pirrone, A. Zamboni, M.C. Veronesi. - In: REPRODUCTION IN DOMESTIC ANIMALS. - ISSN 0936-6768. - 48:suppl. 1(2013), pp. 115-115. ((Intervento presentato al 17. convegno Annual Conference of the European Society for Domestic Animal Reproduction (ESDAR) tenutosi a Bologna nel 2013.
Abstract:
Uric acid to creatinine ratio (Ua/Cr) and lactate to creatinine ratio (L/ Cr) are diagnostic and prognostic biomarkers of perinatal asphyxia in neonatal human medicine. The aim of this work was to investigate urinary Ua/Cr and L/Cr in healthy and critically ill neonatal foals, and their possible diagnostic and prognostic role. Urines were collected by spontaneous micturition from 20 healthy foals within 24 h of age, and daily until day 7. Urines were also collected at admission and between 24 and 36 h after admission from 24 critically ill foals hospitalized within 3 days after birth. Ten foals were affected by perinatal asphyxia and 14 by septicemia. Critically ill foals showed significantly (p < 0.05) higher levels of Ua/Cr during the first 2 days after birth; moreover non-surviving foals (n = 4 with septicemia) hospitalized within 24 h after birth showed significantly (p < 0.05) higher levels compared to survivors (n = 20). Higher L/Cr levels were found in critically ill and non-surviving foals, but no significant differences were found, probably due to the high individual variability. In conclusion, the Ua/Cr ratio could represent an early diagnostic and prognostic marker of disease in newborn foals.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
neonatal foals; urinary uric acid; creatinine; lactate
Elenco autori:
C. Castagnetti, S. Panzani, P. Scarpa, C. Pirrone, A. Zamboni, M.C. Veronesi
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