Data di Pubblicazione:
2014
Citazione:
Orbital liposarcoma in a dog : a case report / A. Crotti, C. Giudice. - In: VETERINARY OPHTHALMOLOGY. - ISSN 1463-5216. - 17:1(2014), pp. 8.E10-8.E10. (Intervento presentato al convegno Annual Scientific Meeting of the European College of Veterinary Opthalmologists tenutosi a Barcelona (Spain) nel 2013) [10.1111/vop.12135].
Abstract:
Purpose: To report a case of primary canine orbital liposarcoma. Methods: A middle
aged female-spayed mongrel dog, from the public kennel, was referred with a history of
swelling and opacity of the left eye that had worsened over the past 2 months. Results: No
abnormalities were detected on general clinical examination. Mouth opening was not painful
and examination of the oral cavity was unremarkable. Ophthalmic examination showed
severe left exophthalmos with reduced globe retropulsion and central exposure keratitis. Corneal
opacification prevented posterior segment examination. An orbital space occupying
lesion was diagnosed, further diagnostic tests were declined by the kennel handler due to
financial constraints. Enucleation was performed. A retrobulbar, multilobulated mass,
2.5 9 3 9 3 cm, was excised along with the globe and formalin- fixed. Histologically, the
mass was composed of dense sheets of large polygonal cells separated by thin fibrous stroma.
Cells have well defined borders, abundant vacuolated cytoplasm and small, peripheral nuclei.
Cell atypia was mild, mitoses <1/10 HPF. Immunohistochemically neoplastic cells were negative
for pancytokeratin and desmin, positive for vimentin and S100; a well differentiated
orbital liposarcoma was therefore diagnosed. The dog recovered uneventfully from surgery
and no recurrence has been noted after 8 months. Conclusions: Liposarcoma is a common
soft-tissue sarcoma but only rarely detected in the orbit. In men, its outcome is dependent
on tumor dimension (<5 cm) and histologic subtype. In the present case neither recurrence
nor signs of metastases were detected 8 months from diagnosis.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
A. Crotti, C. Giudice
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