Data di Pubblicazione:
2014
Citazione:
Is it time to revise antiretrovirals dosing? : a pharmacokinetic viewpoint / D. Cattaneo, S. Baldelli, S. Castoldi, N. Charbe, V. Cozzi, S. Fucile, E. Clementi. - In: AIDS. - ISSN 1473-5571. - 28:16(2014 Oct 23), pp. 2477-2480.
Abstract:
We document our experience with therapeutic drug monitoring (TDM) of antiretroviral agents (1807 determinations) carried out as day-by-day clinical practice for the optimization of drug dosing in HIV-infected patients. A significant proportion of patients had lopinavir, atazanavir and nevirapine trough concentrations exceeding the upper therapeutic threshold. Further studies are needed to identify good candidates/drugs for TDM, eventually allowing the selection of patients who may benefit from TDM-driven adjustments in antiretrovirals dosage.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Anti-Retroviral Agents; Drug Monitoring; HIV Infections; Humans; Lopinavir; Nevirapine; Oligopeptides; Plasma; Pyridines; Retrospective Studies
Elenco autori:
D. Cattaneo, S. Baldelli, S. Castoldi, N. Charbe, V. Cozzi, S. Fucile, E. Clementi
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