Introducing the Tehran Heart Center's premature coronary atherosclerosis cohort: THC-PAC study
Articolo
Data di Pubblicazione:
2015
Citazione:
Introducing the Tehran Heart Center's premature coronary atherosclerosis cohort: THC-PAC study / S.H. Abbasi, S.E. Kassaian, S. Sadeghian, A. Karimi, S. Saadat, F. Peyvandi, A. Jalali, T. Davarpasand, N. Shahmansouri, M. Lotfi Tokaldany, M.A. Abchouyeh, F.A. Isfahani, F. Rosendaal. - In: THE JOURNAL OF TEHRAN UNIVERSITY HEART CENTER. - ISSN 1735-8620. - 10:1(2015), pp. 34-42.
Abstract:
Conclusion: Our younger patients with CAD had a high frequency of risk factors compared to the same-age general population and all-age CAD patients, which may predispose them to higher incidence of recurrent MACE.
Results: The cohort comprises 1232 eligible patients (613 [49.8%] males) at a mean age of 45.1 years (SD = 5.8). High frequencies of conventional risk factors, including hyperlipidemia (884 [71.8%]), hypertension (575 [46.7%]), positive family history (539 [43.8%]), cigarette smoking (479 [38.8%]), and diabetes mellitus (390 [31.7%]), were seen in the participants. The mean body mass index (BMI) of the enrolled patients was high (29.2 ± 4.8 kg/m2), and 532 (43.3%) and 440 (35.8%) of them were overweight and obese, respectively. The females’ BMI was higher (30.4 ± 5.3 vs. 28.0 ± 3.9 kg/m2; P < 0.001) and they had a greater mean abdominal circumference (99.9 ± 13.5 vs. 98.1 ± 9.3 cm; P = 0.035). Between August 2012 and August 2013, follow-up was successful in 1173 (95.2%) patients (median follow-up duration = 55.3 months, 95%CI: 53.5-57.0 months).
Methods: The cohort consists of CAD patients, males ≤ 45 years old and females ≤ 55 years old. The participants are residents of Tehran or its suburbs and underwent coronary angiography between June 2004 and July 2011. A 10-year follow-up, via either clinical visits or telephone calls at least once a year, was commenced in August
2012. The end point is considered MACE, encompassing death, myocardial infarction, stroke, new coronary involvement, percutaneous coronary intervention, and coronary artery bypass grafting.
Background: Data on premature coronary artery disease (CAD) are scarce. The Tehran Heart Center's Premature Coronary Atherosclerosis Cohort Study (THC-PAC) is the first study of its kind in the Middle East to assess major adverse cardiac events (MACE) in young CAD patients.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Cohort studies; Coronary artery disease; Epidemiologic studies; Young adult
Elenco autori:
S.H. Abbasi, S.E. Kassaian, S. Sadeghian, A. Karimi, S. Saadat, F. Peyvandi, A. Jalali, T. Davarpasand, N. Shahmansouri, M. Lotfi Tokaldany, M.A. Abchouyeh, F.A. Isfahani, F. Rosendaal
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