Time course of proadrenomedullin in the early phase of septic shock : a comparative study with other proinflammatory proteins
Articolo
Data di Pubblicazione:
2012
Citazione:
Time course of proadrenomedullin in the early phase of septic shock : a comparative study with other proinflammatory proteins / R. Pezzilli, A. Barassi, A. Pigna, A.M. Morselli-Labate, A. Imbrogno, D. Fabbri, G.D.I. Nino, R. Corinaldesi, G. Melzi D'Eril. - In: PANMINERVA MEDICA. - ISSN 0031-0808. - 54:3(2012 Sep), pp. 211-217.
Abstract:
AIM:
It has been shown that pro-adrenomedullin is a good marker of the severity of septic shock but there are no data on the early changes in serum pro-adrenomedullin concentrations in patients with shock.
METHODS:
Twenty-one patients with septic shock and 21 healthy subjects studied as controls. Serum concentrations of pro-adrenomedullin, procalcitonin, ferritin, CRP and IL-6 were determined in all subjects at the initial observation. Patients with septic shock were also studied after 24 and 48 hours.
RESULTS:
The concentrations of the acute phase proteins were significantly higher in patients with septic shock than in the control subjects during the entire study period (P<0.001). Only procalcitonin significantly decreased on the third day of observation with respect to both the first day (P=0.002) and the second day (P=0.006). Proadrenomedullin (P=0.017) and IL-6 (P=0.001) showed an AUC significantly different from the null hypothesis in differentiating the patients who survived and those who did not. The sensitivity and specificity of pro-adrenomedullin in the assessment of death were 71.4% and 72.7%, respectively, while IL-6 had a sensitivity of 92.9% and a specificity of 60.6%.
CONCLUSION:
Proadrenomedullin is a reliable prognostic marker in patients with shock; further studies on a more consistent number of septic patients will definitively assess whether proadrenomedullin may replace the current prognostic markers in critically ill patients with shock due to sepsis
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Acute-phase proteins; Clinical medicine; Shock sepsis; Medicine (all)
Elenco autori:
R. Pezzilli, A. Barassi, A. Pigna, A.M. Morselli-Labate, A. Imbrogno, D. Fabbri, G.D.I. Nino, R. Corinaldesi, G. Melzi D'Eril
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