Evaluation of equations for measuring eGFR based on serum creatinine and 6 cystatin C values in top level rugby players
Articolo
Data di Pubblicazione:
2010
Citazione:
Evaluation of equations for measuring eGFR based on serum creatinine and 6 cystatin C values in top level rugby players / G. Banfi, G. Melegati, G.V. Melzi d'Eril, A. Barassi. - In: JOURNAL OF HUMAN SPORT AND EXERCISE. - ISSN 1988-5202. - 5:3(2010 Jan), pp. 370-378. [10.4100/jhse.2010.53.07]
Abstract:
Evaluation of equations for measuring eGFR based on serum
creatinine and 6 cystatin C values in top level rugby players. J. Hum. Sport Exerc. Vol. 5, No. 3, pp. 370-
378, 2010. Equations to estimate the glomerular filtration rate (GFR) have recently been advocated over
serum creatinine values as a means to more accurately assess kidney function. The Cockcroft-Gault (CG)
equation requires a body weight parameter, whereas the Modification of Diet in Renal Disease (MDRD)
Study and Mayo Clinic Quadratic Equation (MCQE) formulae do not. We measured the serum creatinine
and cystatin C concentrations in male athletes belonging to the Italian National Rugby team. Blood was
obtained before the start of training and during competitive season. The serum creatinine level was
measured by Jaffe and enzymatic reactions, cystatin C by nefelometry. The same parameters were
measured in a control group of male, sedentary and overweight subjects. The concentrations of cystatin C
were always into the reference ranges. The concentrations of creatinine were often higher than reference
interval. The use of enzymatic method did not improve the specificity. The equations based on cystatin C
and creatinine were not correlated. The two equations based on cystatin C were correlated. Two equations
based on creatinine values were correlated (MDRD and MCQE); they were not correlated with CG. 29 level
athletes, characterized from a high release of creatinine. The use of equations should be accurately
evaluated: the CG equation can overestimate the eGFR, the MDRD and MCQE formulae systematically
underestimates it. The use of equations to estimate GFR in the general population needs examination of
their behaviour in subjects having atypical anthropomorphic characteristics.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
creatinine; cystatin C; rugby; athletes; EGFR
Elenco autori:
G. Banfi, G. Melegati, G.V. Melzi d'Eril, A. Barassi
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