Movement-related frequency modulation of beta oscillatory activity in the human subthalamic nucleus
Articolo
Data di Pubblicazione:
2005
Citazione:
Movement-related frequency modulation of beta oscillatory activity in the human subthalamic nucleus / G. Foffani, A. M. Bianchi, G. Baselli, A. Priori. - In: THE JOURNAL OF PHYSIOLOGY. - ISSN 0022-3751. - 568:2(2005 Oct), pp. 699-711. [10.1113/jphysiol.2005.089722]
Abstract:
Event-related changes of brain electrical rhythms are typically analysed as amplitude
modulations of local field potential (LFP) oscillations, like radio amplitude modulation broadcasting. In telecommunications, frequency modulation (FM) is less susceptible to
interference than amplitude modulation (AM) and is therefore preferred for high-fidelity
transmissions. Here we hypothesized that LFP rhythms detected from deep brain stimulation (DBS) electrodes implanted in the subthalamic nucleus (STN) in patients with Parkinson’s disease could represent movement-related activity not only in AM but also in FM. By combining adaptive autoregressive identification with spectral power decomposition, we were able to show
that FM of low-beta (13–20 Hz) and high-beta (20–35 Hz) rhythms significantly contributes to the involvement of the human STN in movement preparation, execution and recovery, and that the FM patterns are regulated by the dopamine levels in the system. Movement-related FM of beta oscillatory activity in the human subthalamic nucleus therefore provides a novel informational domain for rhythm-based pathophysiological models of cortico-basal ganglia processing.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
G. Foffani, A.M. Bianchi, G. Baselli, A. Priori
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