N-Acetyltransferase-2, glutathione S-transferase M1 and T1 genetic polymorphisms, cigarette smoking and hepatocellular carcinoma: A case-control study
Articolo
Data di Pubblicazione:
2005
Citazione:
N-Acetyltransferase-2, glutathione S-transferase M1 and T1 genetic polymorphisms, cigarette smoking and hepatocellular carcinoma: A case-control study / U. Gelatti, L. Covolo, R. Talamini, A. Tagger, F. Barbone, C. Martelli, F. Cremaschini, S. Franceschi, M.L. Ribero, S. Garte, G. Nardi, V. Donadon, F. Donato. - In: INTERNATIONAL JOURNAL OF CANCER. - ISSN 0020-7136. - 115:2(2005), pp. 301-306. [10.1002/ijc.20895]
Abstract:
Our aim was to evaluate the role of N-acetyltransferase (NAT2) and glutathione S-transferase M1 and T1 (GSTM1 and GSTT1) polymorphisms in hepatocellular carcinoma (HCC) according to cigarette smoking, taking into account hepatitis B (HBV) and C (HCV) viral infection as well as alcohol consumption. A hospital-based case-control study was conducted in 2 areas of north Italy. Cases (n = 200) were patients hospitalized for HCC, and controls (n = 400) were patients admitted for reasons other than liver disease, neoplasms and tobacco- and alcohol-related diseases. Genotypes were determined using PCR and the PCR/restriction fragment length polymorphism-based method. The putative risk genotypes NAT2 slow acetylator, GSTM1 null and GSTT1 null were not associated with HCC (OR = 1.3, 95% CI 0.8-2.0; OR = 1.0, 95% CI 0.6-1.5; OR = 0.8, 95% CI 0.4-1.4, respectively). Although not statistically significant, an increase in HCC risk was observed among light smokers (1-20 pack-years) carrying GSTT1 null (OR = 1.7, 95% CI 0.6-4.7) and NAT2 slow acetylator (OR = 1.3, 95% CI 0.6-3.0) genotypes. In conclusion, there was no evidence for a gene-environment interaction in HCC risk for GSTM1, GSTT1 and NAT2 genotypes.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Case-control study; Epidemiology; Gene-environment interaction; Liver cancer
Elenco autori:
U. Gelatti, L. Covolo, R. Talamini, A. Tagger, F. Barbone, C. Martelli, F. Cremaschini, S. Franceschi, M.L. Ribero, S. Garte, G. Nardi, V. Donadon, F. Donato
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