Preliminary experience with the smooth muscle troponin-like protein, calponin, as a novel biomarker for diagnosing acute aortic dissection
Articolo
Data di Pubblicazione:
2008
Citazione:
Preliminary experience with the smooth muscle troponin-like protein, calponin, as a novel biomarker for diagnosing acute aortic dissection / T. Suzuki, A. Distante, A. Zizza, S. Trimarchi, M. Villani, J.A. Salerno Uriarte, L. De Luca Tupputi Schinosa, A. Renzulli, F. Sabino, R. Nowak, R. Birkhahn, J.E. Hollander, F. Counselman, E. Bossone, K. Eagle. - In: EUROPEAN HEART JOURNAL. - ISSN 0195-668X. - 29:11(2008 Jun), pp. 1439-1445. [10.1093/eurheartj/ehn162]
Abstract:
Aims: The early diagnosis of acute aortic dissection (AD) remains challenging. We sought to determine the utility of the troponin-like protein of smooth muscle, calponin, as a diagnostic biomarker of acute AD. Methods and results: Immunoassays against calponin (acidic, basic, and neutral isoforms) were developed and the levels were compared in a convenience sample of 59 patients with radiographically proven AD [34 males, age 59 ± 15 (SD) years] vs. 158 patients suspected of having AD at presentation (116 males, age 63 ± 15 years) but whose final diagnosis was not AD. Basic calponin, which is the most specific and abundant in smooth muscle, and acidic calponin, respectively, showed greater than two-fold and three-fold elevations in patients with acute AD. Diagnostic performance as determined by receiver-operating characteristics curve analysis showed that both acidic and basic calponin have the potential to detect AD in the first 24 h [respective areas under the curve (AUCs) 0.63 and 0.58], with superior performance of basic calponin (when compared with acidic) in the initial 6 h (respective AUCs 0.63 and 0.67). Conclusion: Circulating calponin levels were elevated in acute AD compared with controls. These biomarkers have the potential for use as an early diagnostic biomarker for acute AD.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Aortic dissection; Biomarker
Elenco autori:
T. Suzuki, A. Distante, A. Zizza, S. Trimarchi, M. Villani, J.A. Salerno Uriarte, L. De Luca Tupputi Schinosa, A. Renzulli, F. Sabino, R. Nowak, R. Birkhahn, J.E. Hollander, F. Counselman, E. Bossone, K. Eagle
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