Data di Pubblicazione:
2015
Citazione:
Genetic studies of body mass index yield new insights for obesity biology / A.E. Locke, B. Kahali, S.I. Berndt, A.E. Justice, T.H. Pers, F.R. Day, C. Powell, S. Vedantam, M.L. Buchkovich, J. Yang, D.C. Croteau-Chonka, T. Esko, T. Fall, T. Ferreira, S. Gustafsson, Z. Kutalik, J. Luan, R. Mägi, J.C. Randall, T.W. Winkler, A.R. Wood, T. Workalemahu, J.D. Faul, J.A. Smith, J.H. Zhao, W. Zhao, J. Chen, R. Fehrmann, Å.K. Hedman, J. Karjalainen, E.M. Schmidt, D. Absher, N. Amin, D. Anderson, M. Beekman, J.L. Bolton, J.L. Bragg-Gresham, S. Buyske, A. Demirkan, G. Deng, G.B. Ehret, B. Feenstra, M.F. Feitosa, K. Fischer, A. Goel, J. Gong, A.U. Jackson, S. Kanoni, M.E. Kleber, K. Kristiansson, U. Lim, V. Lotay, M. Mangino, I.M. Leach, C. Medina-Gomez, S.E. Medland, M.A. Nalls, C.D. Palmer, D. Pasko, S. Pechlivanis, M.J. Peters, I. Prokopenko, D. Shungin, A. Stančáková, R.J. Strawbridge, Y.J. Sung, T. Tanaka, A. Teumer, S. Trompet, S.W. Van Der Laan, J. Van Setten, J.V. Van Vliet-Ostaptchouk, Z. Wang, L. Yengo, W. Zhang, A. Isaacs, E. Albrecht, J. Ärnlöv, G.M. Arscott, A.P. Attwood, S. Bandinelli, A. Barrett, I.N. Bas, C. Bellis, A.J. Bennett, C. Berne, R. Blagieva, M. Blüher, S. Böhringer, L.L. Bonnycastle, Y. Böttcher, H.A. Boyd, M. Bruinenberg, I.H. Caspersen, Y.I. Chen, R. Clarke, E..W. Daw, A.J.M. De Craen, G. Delgado, M. Dimitriou, A.S.F. Doney, N. Eklund, K. Estrada, E. Eury, L. Folkersen, R.M. Fraser, M.E. Garcia, F. Geller, V. Giedraitis, B. Gigante, A.S. Go, A. Golay, A.H. Goodall, S.D. Gordon, M. Gorski, H. Grabe, H. Grallert, T.B. Grammer, J. Gräßler, H. Grönberg, C.J. Groves, G. Gusto, J. Haessler, P. Hall, T. Haller, G. Hallmans, C.A. Hartman, M. Hassinen, C. Hayward, N.L. Heard-Costa, Q. Helmer, C. Hengstenberg, O. Holmen, J. Hottenga, A.L. James, J.M. Jeff, Å. Johansson, J. Jolley, T. Juliusdottir, L. Kinnunen, W. Koenig, M. Koskenvuo, W. Kratzer, J. Laitinen, C. Lamina, K. Leander, N.R. Lee, P. Lichtner, L. Lind, J. Lindström, K.S. Lo, S. Lobbens, R. Lorbeer, Y. Lu, F. Mach, P.K.E. Magnusson, A. Mahajan, W.L. Mcardle, S. Mclachlan, C. Menni, S. Merger, E. Mihailov, L. Milani, A. Moayyeri, K.L. Monda, M.A. Morken, A. Mulas, G. Müller, M. Müller-Nurasyid, A.W. Musk, R. Nagaraja, M.M. Nöthen, I.M. Nolte, S. Pilz, N.W. Rayner, F. Renstrom, R. Rettig, J.S. Ried, S. Ripke, N.R. Robertson, L.M. Rose, S. Sanna, H. Scharnagl, S. Scholtens, F.R. Schumacher, W.R. Scott, T. Seufferlein, J. Shi, A.V. Smith, J. Smolonska, A.V. Stanton, V. Steinthorsdottir, K. Stirrups, H.M. Stringham, J. Sundström, M.A. Swertz, A.J. Swift, A. Syvänen, S. Tan, B.O. Tayo, B. Thorand, G. Thorleifsson, J.P. Tyrer, H. Uh, L. Vandenput, F.C. Verhulst, S.H. Vermeulen, N. Verweij, J.M. Vonk, L.L. Waite, H.R. Warren, D. Waterworth, M.N. Weedon, L.R. Wilkens, C. Willenborg, T. Wilsgaard, M.K. Wojczynski, A. Wong, A.F. Wright, Q. Zhang, E.P. Brennan, M. Choi, Z. Dastani, A.W. Drong, P. Eriksson, A. Franco-Cereceda, J.R. Gådin, A.G. Gharavi, M.E. Goddard, R.E. Handsaker, J. Huang, F. Karpe, S. Kathiresan, S. Keildson, K. Kiryluk, M. Kubo, J. Lee, L. Liang, R.P. Lifton, B. Ma, S.A. Mccarroll, A.J. Mcknight, J.L. Min, M.F. Moffatt, G.W. Montgomery, J.M. Murabito, G. Nicholson, D.R. Nyholt, Y. Okada, J.R.B. Perry, R. Dorajoo, E. Reinmaa, R.M. Salem, N. Sandholm, R.A. Scott, L. Stolk, A. Takahashi, T. Tanaka, F.M. Va't Hooft, A.A.E. Vinkhuyzen, H. Westra, W. Zheng, K.T. Zondervan, A.C. Heath, D. Arveiler, S.J.L. Bakker, J. Beilby, R.N. Bergman, J. Blangero, P. Bovet, H. Campbell, M.J. Caulfield, G. Cesana, A. Chakravarti, D.I. Chasman, P.S. Chines, F.S. Collins, D.C. Crawford, L..A. Cupples, D. Cusi, J. Danesh, U. De Faire, H.M. Den Ruijter, A.F. Dominiczak, R. Erbel, J. Erdmann, J.G. Eriksson, M. Farrall, S.B. Felix, E. Ferrannini, J. Ferrières, I. Ford, N.G. Forouhi, T. Forrester, O.H. Franco, R.T. Gansevoort, P.V. Gejman, C. Gieger, O. Gottesman, V. Gudnason, U. Gyllensten, A.S. Hall, T.B. Harris, A.T. Hattersley, A
Abstract:
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10-8), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Adipogenesis; Adiposity; Age Factors; Continental Population Groups; Energy Metabolism; Europe; Female; Genetic Predisposition to Disease; Glutamic Acid; Humans; Insulin; Male; Obesity; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Synapses; Body Mass Index; Genome-Wide Association Study; Multidisciplinary
Elenco autori:
A.E. Locke, B. Kahali, S.I. Berndt, A.E. Justice, T.H. Pers, F.R. Day, C. Powell, S. Vedantam, M.L. Buchkovich, J. Yang, D.C. Croteau Chonka, T. Esko, T. Fall, T. Ferreira, S. Gustafsson, Z. Kutalik, J. Luan, R. Mägi, J.C. Randall, T.W. Winkler, A.R. Wood, T. Workalemahu, J.D. Faul, J.A. Smith, J.H. Zhao, W. Zhao, J. Chen, R. Fehrmann, Å.K. Hedman, J. Karjalainen, E.M. Schmidt, D. Absher, N. Amin, D. Anderson, M. Beekman, J.L. Bolton, J.L. Bragg Gresham, S. Buyske, A. Demirkan, G. Deng, G.B. Ehret, B. Feenstra, M.F. Feitosa, K. Fischer, A. Goel, J. Gong, A.U. Jackson, S. Kanoni, M.E. Kleber, K. Kristiansson, U. Lim, V. Lotay, M. Mangino, I.M. Leach, C. Medina Gomez, S.E. Medland, M.A. Nalls, C.D. Palmer, D. Pasko, S. Pechlivanis, M.J. Peters, I. Prokopenko, D. Shungin, A. Stančáková, R.J. Strawbridge, Y.J. Sung, T. Tanaka, A. Teumer, S. Trompet, S.W. Van Der Laan, J. Van Setten, J.V. Van Vliet Ostaptchouk, Z. Wang, L. Yengo, W. Zhang, A. Isaacs, E. Albrecht, J. Ärnlöv, G.M. Arscott, A.P. Attwood, S. Bandinelli, A. Barrett, I.N. Bas, C. Bellis, A.J. Bennett, C. Berne, R. Blagieva, M. Blüher, S. Böhringer, L.L. Bonnycastle, Y. Böttcher, H.A. Boyd, M. Bruinenberg, I.H. Caspersen, Y.I. Chen, R. Clarke, E..W. Daw, A.J.M. De Craen, G. Delgado, M. Dimitriou, A.S.F. Doney, N. Eklund, K. Estrada, E. Eury, L. Folkersen, R.M. Fraser, M.E. Garcia, F. Geller, V. Giedraitis, B. Gigante, A.S. Go, A. Golay, A.H. Goodall, S.D. Gordon, M. Gorski, H. Grabe, H. Grallert, T.B. Grammer, J. Gräßler, H. Grönberg, C.J. Groves, G. Gusto, J. Haessler, P. Hall, T. Haller, G. Hallmans, C.A. Hartman, M. Hassinen, C. Hayward, N.L. Heard Costa, Q. Helmer, C. Hengstenberg, O. Holmen, J. Hottenga, A.L. James, J.M. Jeff, Å. Johansson, J. Jolley, T. Juliusdottir, L. Kinnunen, W. Koenig, M. Koskenvuo, W. Kratzer, J. Laitinen, C. Lamina, K. Leander, N.R. Lee, P. Lichtner, L. Lind, J. Lindström, K.S. Lo, S. Lobbens, R. Lorbeer, Y. Lu, F. Mach, P.K.E. Magnusson, A. Mahajan, W.L. Mcardle, S. Mclachlan, C. Menni, S. Merger, E. Mihailov, L. Milani, A. Moayyeri, K.L. Monda, M.A. Morken, A. Mulas, G. Müller, M. Müller Nurasyid, A.W. Musk, R. Nagaraja, M.M. Nöthen, I.M. Nolte, S. Pilz, N.W. Rayner, F. Renstrom, R. Rettig, J.S. Ried, S. Ripke, N.R. Robertson, L.M. Rose, S. Sanna, H. Scharnagl, S. Scholtens, F.R. Schumacher, W.R. Scott, T. Seufferlein, J. Shi, A.V. Smith, J. Smolonska, A.V. Stanton, V. Steinthorsdottir, K. Stirrups, H.M. Stringham, J. Sundström, M.A. Swertz, A.J. Swift, A. Syvänen, S. Tan, B.O. Tayo, B. Thorand, G. Thorleifsson, J.P. Tyrer, H. Uh, L. Vandenput, F.C. Verhulst, S.H. Vermeulen, N. Verweij, J.M. Vonk, L.L. Waite, H.R. Warren, D. Waterworth, M.N. Weedon, L.R. Wilkens, C. Willenborg, T. Wilsgaard, M.K. Wojczynski, A. Wong, A.F. Wright, Q. Zhang, E.P. Brennan, M. Choi, Z. Dastani, A.W. Drong, P. Eriksson, A. Franco Cereceda, J.R. Gådin, A.G. Gharavi, M.E. Goddard, R.E. Handsaker, J. Huang, F. Karpe, S. Kathiresan, S. Keildson, K. Kiryluk, M. Kubo, J. Lee, L. Liang, R.P. Lifton, B. Ma, S.A. Mccarroll, A.J. Mcknight, J.L. Min, M.F. Moffatt, G.W. Montgomery, J.M. Murabito, G. Nicholson, D.R. Nyholt, Y. Okada, J.R.B. Perry, R. Dorajoo, E. Reinmaa, R.M. Salem, N. Sandholm, R.A. Scott, L. Stolk, A. Takahashi, T. Tanaka, F.M. Va't Hooft, A.A.E. Vinkhuyzen, H. Westra, W. Zheng, K.T. Zondervan, A.C. Heath, D. Arveiler, S.J.L. Bakker, J. Beilby, R.N. Bergman, J. Blangero, P. Bovet, H. Campbell, M.J. Caulfield, G. Cesana, A. Chakravarti, D.I. Chasman, P.S. Chines, F.S. Collins, D.C. Crawford, L..A. Cupples, D. Cusi, J. Danesh, U. De Faire, H.M. Den Ruijter, A.F. Dominiczak, R. Erbel, J. Erdmann, J.G. Eriksson, M. Farrall, S.B. Felix, E. Ferrannini, J. Ferrières, I. Ford, N.G. Forouhi, T. Forrester, O.H. Franco, R.T. Gansevoort, P.V. Gejman, C. Gieger, O. Gottesman, V. Gudnason, U. Gyllensten, A.S. Hall, T.B. Harris, A.T. Hattersley, A.A. Hicks, L.A. Hindorff, A.D. Hingorani, A. Hofman, G. Homuth, G..K. Hoving
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