Candidaemia observed at a University Hospital in Milan (Northern Italy) and review of published studies from 2010 to 2014
Articolo
Data di Pubblicazione:
2014
Citazione:
Candidaemia observed at a University Hospital in Milan (Northern Italy) and review of published studies from 2010 to 2014 / L. Milazzo, A.M. Peri, C. Mazzali, R. Grande, C. Cazzani, D. Ricaboni, A. Castelli, F. Raimondi, C. Magni, M. Galli, S. Antinori. - In: MYCOPATHOLOGIA. - ISSN 0301-486X. - 178:3/4(2014 Oct), pp. 227-241.
Abstract:
BACKGROUND:
Candida species represent the fourth leading cause of nosocomial bloodstream infections (BSI) worldwide. However, candidaemia rates and species involved vary geographically.
OBJECTIVES:
To evaluate the epidemiological pattern, risk factors for mortality and antifungal therapy of Candida BSI over a 5-year period (2008-2012) in a university hospital in northern Italy together with a review of the recent literature concerning candidaemia.
METHODS:
A retrospective cohort study cross-linked with microbiology database was performed.
RESULTS:
A total of 89 Candida BSI were identified in 42 males (47 %) and 47 females (52.8 %). The median age was 69 years (interquartile range 55-78) with 61.8 % of patients being older than 65 years. Considering all hospitalized patients, the overall incidence rate of candidaemia increased significantly from 2008 to 2012 (from 0.4 to 1.68 episodes per 10,000 patient/days) (p = 0.0001) with a mean linear increase in 5 new cases per year. Candida albicans was the predominant species isolated (64 %) followed by C. glabrata (19.1 %). The latter species was observed with significantly higher frequency in Internal Medicine and Intensive Care Units (ICU). In-hospital crude mortality was 41.6 %.
CONCLUSIONS:
Candidaemia is an increasing BSI in our university hospital, in accordance with that observed in northern Italy, and it is still associated with high in-hospital crude mortality.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
candidaemia; fungal infections; C. albicans; C. glabrata; C. parapsilosis; intensive care unit
Elenco autori:
L. Milazzo, A.M. Peri, C. Mazzali, R. Grande, C. Cazzani, D. Ricaboni, A. Castelli, F. Raimondi, C. Magni, M. Galli, S. Antinori
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