Deep brain stimulation of the nucleus accumbens and bed nucleus of stira terminalis for obsessive-compulsive disorder: a case series
Articolo
Data di Pubblicazione:
2015
Citazione:
Deep brain stimulation of the nucleus accumbens and bed nucleus of stira terminalis for obsessive-compulsive disorder: a case series / L. Islam, A. Franzini, G. Messina, S. Scarone, O. Gambini. - In: WORLD NEUROSURGERY. - ISSN 1878-8750. - 83:45(2015), pp. 657-663. [10.1016/j.wneu.2014.12.024]
Abstract:
Background
Obsessive-compulsive disorder (OCD) is a psychiatric condition defined by the presence of obsessions, compulsions, or both. It has a lifetime prevalence of 2%–3% and causes significant impairment in social and work functioning, as well as a reduced quality of life. Treatment includes pharmacotherapy and psychotherapy, but a significant number of patients fail to respond to treatment. Deep brain stimulation has shown to be a safe and effective procedure for severe, chronic, treatment-resistant OCD, and several surgical targets have been proposed for treatment, including the nucleus accumbens, the anterior limb of the internal capsule, the subthalamic nucleus, the globus pallidus, and the bed nucleus of stria terminalis.
Objectives
To report the first Italian case series of patients who underwent DBS of 2 distinct targets for OCD: nulceus accumbens and bed nulceus of stria terminalis. METHODS: Four patients underwent DBS of the nulceus accumbens, and 4 patients underwent DBS of the bed nucleus of stria terminalis.
Results
Six patients showed a significant improvement in OCD symptoms. CONCLUSIONS: DBS of these 2 structures is a safe and effective procedure for the treatment of severe, refractory OCD.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Bed nucleus stria terminalis; Deep brain stimulation; Nucleus accumbens; Obsessive-compulsive disorder
Elenco autori:
L. Islam, A. Franzini, G. Messina, S. Scarone, O. Gambini
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