Modulation of the glutamatergic transmission by Dopamine: a focus on Parkinson, Huntington and Addiction diseases
Articolo
Data di Pubblicazione:
2015
Citazione:
Modulation of the glutamatergic transmission by Dopamine: a focus on Parkinson, Huntington and Addiction diseases / F. Gardoni, C. Bellone. - In: FRONTIERS IN CELLULAR NEUROSCIENCE. - ISSN 1662-5102. - 9:(2015), pp. 25.1-25.11. [10.3389/fncel.2015.00025]
Abstract:
Dopamine (DA) plays a major role in motor and cognitive functions as well as in reward processing by regulating glutamatergic inputs. In particular in the striatum the release of DA rapidly influences synaptic transmission modulating both AMPA and NMDA receptors. Several neurodegenerative and neuropsychiatric disorders, including Parkinson, Huntington and addiction-related diseases, manifest a dysregulation of glutamate and DA signaling. Here, we will focus our attention on the mechanisms underlying the modulation of the glutamatergic transmission by DA in striatal circuits.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
AMPA receptors; Addiction; Dopamine; Huntington disease; NMDA receptor; Parkinson disease
Elenco autori:
F. Gardoni, C. Bellone
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