"In situ" activation of racemic Ru(II) complexes : separation of trans and cis species and their application in asymmetric reduction
Abstract
Data di Pubblicazione:
2012
Citazione:
"In situ" activation of racemic Ru(II) complexes : separation of trans and cis species and their application in asymmetric reduction / G. Facchetti, E. Cesarotti, M. Pellizzoni, D. Zerla, I. Rimoldi - In: Congresso del gruppo interdivisionale di Chimica Organometallica : abstracts[s.l] : Società Chimica Italiana, 2012 Jun 05. - pp. 69-69 (( Intervento presentato al 10. convegno Co.G.I.C.O. tenutosi a Padova nel 2012.
Abstract:
Over the last two decades new catalytically active Ru(II)-complexes characterised by the combination of a chiral diphosphine containing a chiral chelating diamine were developed1,2. These complexes are very suitable as pre-catalysts for asymmetric hydrogenation of acetophenone-like ketones, whose corresponding alcohols are important building-blocks for industrial and pharmaceutical applications. A drawback to this ground breaking discovery is frequently related to the expense of isolating the two pure chiral ligands.
This research has been conducted to resolve Ru(II)-complexes where the ligand is a racemic atropisomeric diphosphine in combination with a chiral diamine (1,2-diphenyl-ethylenediamine, DPEN).
Despite the expected presence of trans species, results unexpectantly unveiled a cis-species with low basic atropoisomeric ligands like BITIANP and BIMIP. The complete isolation of cis- and trans-themodinamically favoured isomers was achieved and their use in asymmetric reductions of standard substrate was evaluated.
Tipologia IRIS:
03 - Contributo in volume
Elenco autori:
G. Facchetti, E. Cesarotti, M. Pellizzoni, D. Zerla, I. Rimoldi
Link alla scheda completa:
Titolo del libro:
Congresso del gruppo interdivisionale di Chimica Organometallica : abstracts