C-3 functionalization of indoles with methyl 2-acetamidoacrylate under Gold(I), Silver or Brønsted acids catalysis
Contributo in Atti di convegno
Data di Pubblicazione:
2014
Citazione:
C-3 functionalization of indoles with methyl 2-acetamidoacrylate under Gold(I), Silver or Brønsted acids catalysis / V. Pirovano, M. Dell'Acqua, G. Abbiati, E. Rossi - In: Co.Gi.Co 2014, XI Congresso del Gruppo Interdivisionale di Chimica Organometallica Milano 24-27 Giugno 2014 / [a cura di] E. Licandro, F. Ragaini. - [s.l] : Edises, 2014 Jul. - ISBN 9788879598224. - pp. 46-46 (( Intervento presentato al 11. convegno Congresso del gruppo interdivisionale di chimica organometallica tenutosi a Milano nel 2014.
Abstract:
The chemical modification of indoles through direct functionalization of their C–H bonds constitute
a widespread research area of continuous interest for organic synthesis since this scaffold is present in a huge variety of natural product families, medicines or drug candidates, among others. In particular, the formation of a new C–C bond by means of innovative catalytic systems represents an alternative to traditional Friedel-Crafts reactions and allows the use of less toxic reagents and to
operate in milder conditions. Among metals, gold catalysts have been employed to this scope in the
last years. In our research group, in particular, we get interested in investigating the reactivity of
indoles towards α-amidoacrylates, as specific class of enones, in the presence of gold or silver
catalysts. Thus, under the optimized reactions conditions we were able to synthetize a series of α-
indolylacrilates in high yields. Furthermore an acid-catalyzed version of this reaction was also
explored achieving similar results.
Tipologia IRIS:
03 - Contributo in volume
Keywords:
silver catalysis; gold catalysis; broensted acids catalysis; indole functionalization
Elenco autori:
V. Pirovano, M. Dell'Acqua, G. Abbiati, E. Rossi
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Titolo del libro:
Co.Gi.Co 2014, XI Congresso del Gruppo Interdivisionale di Chimica Organometallica Milano 24-27 Giugno 2014