Improvement in symptoms and cochlear flow with pycnogenol in patients with Meniere's disease and tinnitus
Articolo
Data di Pubblicazione:
2014
Citazione:
Improvement in symptoms and cochlear flow with pycnogenol in patients with Meniere's disease and tinnitus / R. Luzzi, G. Belcaro, S. Hu, M. Dugall, M. Hosoi, M. Cacchio, E. Ippolito, M. Corsi. - In: MINERVA MEDICA. - ISSN 0026-4806. - 105:3(2014 Jun), pp. 245-254.
Abstract:
AIM:
The aim of this supplement registry was to evaluate the efficacy of the Pycnogenol® in improving cochlear flow and symptoms in a 6-month follow-up for patients with Meniere's disease (MD), tinnitus and cochlear hypoperfusion.
METHODS:
Main signs/symptoms were considered: Spontaneous vertigo, positional vertigo, hearing loss, tinnitus, pressure in the ear, unsteady gait, associated clinical problems, alterations in daily life. All subjects were managed with the best available management (BM); one group used the supplement Pycnogenol (150 mg/day). Cochlear flow and tinnitus were also evaluated. Out of 120 patients incuded in the registry, 55 used Pycnogenol and 52 (controls) were managed only with BM.
RESULTS:
There was a more significant improvement in all registry items at 3 and 6 months in the Pycnogenol group (P<0.05). The number of lost working days was lower in the Pycnogenol group. At 3 months, 45.4% of subjects using Pycnogenol were completely asymptomatic in comparison with 23.07% of controls. At 6 months 87.3% of the Pycnogenol subjects were asymptomatic compared with 34.6% of controls. Cochlear flow velocity was significantly better (higher flow, higher diastolic component) in the Pycnogenol group (P<0.05). The subjective tinnitus scale decreased in both groups (P<0.05); the decrease was more significant in Pycnogenol subjects (P<0.05) at 3 and 6 months.
CONCLUSION:
Symptoms of Meniere's disease, flow at cochlear level and tinnitus improved in Pycnogenol subjects in comparison with best management.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Cochlea; Ear, inner; Meniere disease; Perfusion; Pycnogenol; Tinnitus; Ultrasonography, Doppler, Duplex
Elenco autori:
R. Luzzi, G. Belcaro, S. Hu, M. Dugall, M. Hosoi, M. Cacchio, E. Ippolito, M. Corsi
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