Synaptoproteomic analysis of a rat gene-environment model of depression reveals involvement of energy metabolism and cellular remodeling pathways
Articolo
Data di Pubblicazione:
2015
Citazione:
Synaptoproteomic analysis of a rat gene-environment model of depression reveals involvement of energy metabolism and cellular remodeling pathways / A. Mallei, M. Failler, S. Corna, G. Racagni, A.A. Mathé, M. Popoli. - In: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. - ISSN 1461-1457. - 18:3(2015 Feb), pp. pyu067.1-pyu067.21. [10.1093/ijnp/pyu067]
Abstract:
Major depression is a severe mental illness that causes heavy social and economic burden worldwide. A number of studies have shown that interaction between individual genetic vulnerability and environmental risk factors, such as stress, is crucial in psychiatric pathophysiology. In particular, the experience of stressful events in childhood, such as neglect, abuse or parent loss, was found to increase the risk for development of depression in adult life. Here, to reproduce the gene x environment interaction, we employed an animal model that combines genetic vulnerability with early-life stress.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
proteomics; early-life stress; hippocampus; prefrontal and frontal cortex; synaptosome
Elenco autori:
A. Mallei, M. Failler, S. Corna, G. Racagni, A.A. Mathé, M. Popoli
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