Molecular Cooperation to Reinforce Immune Response during Carcinoma: a Structural Bioinformatics Analysis
Capitolo
Data di Pubblicazione:
2014
Citazione:
Molecular Cooperation to Reinforce Immune Response during Carcinoma: a Structural Bioinformatics Analysis / R. Pizzi, T. Rutigliano, P. Guadalupi, M. Pregnolato (MATHEMATICS AND COMPUTERS IN SCIENCE AND ENGINEERING SERIES). - In: International Conference on Applied Mathematics, Simulation, Modelling (ASM '14) / [a cura di] N.E. Mastorakis, M. Demiralp, N. Mukhopadhyay, F. Mainardi. - Athens : WSEAS Press, 2014. - ISBN 9789604743988. - pp. 346-353 (( Intervento presentato al 8. convegno International Conference on Applied Mathematics, Simulation and Modeling tenutosi a Firenze nel 2014.
Abstract:
In the last decades evidence has been found of nervous system–immune system interactions that exists at several biological levels. Many substances seem to be involved in this process, among the others cytokines and melatonin, although no scientific evidence has been fully established. In this study we hypothesize that the efficacy of the neuroendocrine-immune systems interaction may be studied at a membrane receptor level, and could be highlighted by a structural bioinformatics research. In this paper we built a model of the interaction between a lipid membrane with typical gastrointestinal cancer traits, and several substances that are supposed to be involved in the immune response. A computational docking analysis shows that the interaction between melatonin as a neuroendocrine agent, immune substances and mediators of the inflammatory response may have a role in the complex relationship between nervous system and immune system.
Tipologia IRIS:
03 - Contributo in volume
Keywords:
Melatonin; Interleukin; IL-2; cancer; immune system; PNEI; placebo; bioinformatics; docking
Elenco autori:
R. Pizzi, T. Rutigliano, P. Guadalupi, M. Pregnolato
Link alla scheda completa:
Titolo del libro:
International Conference on Applied Mathematics, Simulation, Modelling (ASM '14)