Optimisation study of a-cyclotron production of At-211/Po-211g for high-LET metabolic radiotherapy purposes
Articolo
Data di Pubblicazione:
2005
Citazione:
Optimisation study of a-cyclotron production of At-211/Po-211g for high-LET metabolic radiotherapy purposes / F. Groppi, M.L. Bonardi, C. Birattari, E. Menapace, K. Abbas, U. Holzwarth, A. Alfarano, S. Morzenti, C. Zona, Z.B. Alfassi. - In: APPLIED RADIATION AND ISOTOPES. - ISSN 0969-8043. - 63:5-6(2005 Nov), pp. 621-631.
Abstract:
The production of no-carrier-added (NCA) alpha emitter 211At/211gPo radionuclides for high-LET targeted radiotherapy
and immunoradiotherapy, through the 209Bi(alpha,2n) reaction, together with the required wet radiochemistry
and radioanalytical quality controls carried out at LASA is described, through dedicated irradiation experiments
at the MC-40 cyclotron of JRC-Ispra. The amount of both the gamma-emitter 210At and its long half-lived alpha-emitting
daughter 210Po is optimised and minimised by appropriate choice of energy and energy loss of alpha particle beam. The
measured excitation functions for production of the main radioisotopic impurity 210At- 210Po are compared with
theoretical predictions from model calculations performed at ENEA.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Produzione di No Carrier Added 211At/211gPo, 210At/210Po, reazioni 209Bi(alfa,xn); radioterapia metabolica ad alto LET; funzioni d'eccitazione; bismuto-209; ciclotrone
Elenco autori:
F. Groppi, M.L. Bonardi, C. Birattari, E. Menapace, K. Abbas, U. Holzwarth, A. Alfarano, S. Morzenti, C. Zona, Z.B. Alfassi
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