Data di Pubblicazione:
2015
Citazione:
Impact of needle-like crystals on wet and solid-lipid extrusion processes / G. Di Pretoro, L. Zema, A. Gazzaniga, P. Kleinebudde. - In: POWDER TECHNOLOGY. - ISSN 0032-5910. - 270:special issue(2015 Jan), pp. 476-483. [10.1016/j.powtec.2014.07.047]
Abstract:
The aim of the current work was to investigate systematically the impact of needle-like drug crystals on both wet and solid-lipid extrusion processes. Co-rotating twin-screw extrusion, through 0.5, 0.7 and 1.0 mm multi-holed capillary dies, was therefore used to assess the processability of formulations containing up to 80 wt.% of three needle-like, poorly soluble active ingredients, i.e. mesalamine, nimesulide and praziquantel. Their impact on both wet and solid-lipid extrusions was evaluated prior to and after an appropriate micronisation step aimed at reducing their particle size, and obtaining more isometric particles. Occlusion of die holes and a steady increase in extrusion pressure, whose extent was found to be dependent on both the drug loading and the morphology of the drug's crystal, was observed with all the active ingredients tested. A change in particle morphology, combined to a reduction in particle size, allowed the occlusion of die holes to be considerably reduced and/or prevented, and smooth and robust extrusion processes to be achieved.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Die diameter; Milling; Needle-like particles; Particle shape; Solid-lipid extrusion; Wet extrusion
Elenco autori:
G. Di Pretoro, L. Zema, A. Gazzaniga, P. Kleinebudde
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