Data di Pubblicazione:
2015
Citazione:
Benzodioxane–benzamides as new bacterial cell division inhibitors / G. Chiodini, M. Pallavicini, C. Zanotto, M. Bissa, A. Radaelli, V. Straniero, C. Bolchi, L. Fumagalli, P. Ruggeri, C. De Giuli Morghen, E. Valoti. - In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0223-5234. - 89(2015), pp. 252-265. [10.1016/j.ejmech.2014.09.100]
Abstract:
A SAR study was performed on 3-substituted 2,6-difluorobenzamides, known inhibitors of the essential bacterial cell division protein FtsZ, through a series of modifications first of 2,6-difluoro-3-nonyloxybenzamide and then of its 3-pyridothiazolylmethoxy analogue PC190723. The study led to the identification of chiral 2,6-difluorobenzamides bearing 1,4-benzodioxane-2-methyl residue at the 3 -position as potent antistaphylococcal compounds.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
FtsZ; Antibacterial activity; Benzodioxane; 2,6-Difluorobenzamide; Staphylococcus aureus
Elenco autori:
G. Chiodini, M. Pallavicini, C. Zanotto, M. Bissa, A. Radaelli, V. Straniero, C. Bolchi, L. Fumagalli, P. Ruggeri, C. De Giuli Morghen, E. Valoti
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