Erodible time-dependent colon delivery systems with improved efficiency in delaying the onset of drug release
Articolo
Data di Pubblicazione:
2014
Citazione:
Erodible time-dependent colon delivery systems with improved efficiency in delaying the onset of drug release / M.D. Del Curto, L. Palugan, A. Foppoli, L. Zema, A. Gazzaniga, A. Maroni. - In: JOURNAL OF PHARMACEUTICAL SCIENCES. - ISSN 0022-3549. - 11:103(2014 Sep 11), pp. 3585-3593. [10.1002/jps.24150]
Abstract:
To prepare swellable/erodible time-dependent colon delivery systems with improved efficiency in delaying drug release, the application of an outer Eudragit® NE film, which contained the superdisintegrant Explotab® V17 as a pore former, was attempted. Tablet cores were successively spray-coated with a hydroxypropyl methylcellulose (HPMC) solution and diluted Eudragit® NE 30 D, wherein fixed amounts of Explotab® V17 were present. The resulting two-layer systems yielded lag phases of extended duration as compared with formulations provided with the HPMC layer only. By raising the thickness of the outer film, longer lag times were generally observed, whereas the effectiveness in deferring the drug liberation was reduced by increasing the pore former content, which, however, also resulted in a lower data variability. The films containing 20% of Explotab® V17 effectively and consistently prolonged the in vitro lag phase imparted by HPMC as a function of their thickness. Stored for 3 years under ambient conditions, a two-layer system with this outer film composition pointed out unmodified release patterns. The same system proved to meet gastroresistance criteria when enteric coated. The results obtained indicated that the proposed strategy would enable the preparation of erodible delivery systems with reduced size, possibly suitable as multiple-unit dosage forms.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Colonic drug delivery; Controlled release/delivery; Film-coating; Formulation; Oral drug delivery; Pulsatile/delayed release; Solid dosage form; Swellable/erodible polymeric drug delivery systems
Elenco autori:
M.D. Del Curto, L. Palugan, A. Foppoli, L. Zema, A. Gazzaniga, A. Maroni
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