Data di Pubblicazione:
2014
Citazione:
Simple process for the preparation of cetyltrimethylammonium naproxenate (naprocet) / C. Bolchi, E. Valoti, L. Fumagalli, P. Ruggeri, V. Straniero, M. Pallavicini. - In: ORGANIC PROCESS RESEARCH & DEVELOPMENT. - ISSN 1083-6160. - 18:8(2014 Aug), pp. 976-979. [10.1021/op500175v]
Abstract:
Specifications for cetyltrimethylammonium (CTA) naproxenate (naprocet), the active ingredient of
pharmaceutical liquid preparations used as antiseptic−antinflammatory detergents, fix severe limits to the presence of residual
inorganic counteranion deriving from the starting CTA salt. A new simple procedure, which avoids ionic exchange
chromatography and utilizes CTAHSO4 in place of CTABr and CTACl, exploits the quantitative precipitation of K2SO4 from
methanol to yield naprocet in line with such specification requirements.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
C. Bolchi, E. Valoti, L. Fumagalli, P. Ruggeri, V. Straniero, M. Pallavicini
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