Data di Pubblicazione:
2014
Citazione:
Failure of Miltefosine treatment in two dogs with natural Leishmania infantum infection / D. Proverbio, E. Spada, G. Bagnagatti De Giorgi, R. Perego. - In: CASE REPORTS IN VETERINARY MEDICINE. - ISSN 2090-701X. - 2014:(2014), pp. 640151.1-640151.6. [10.1155/2014/640151]
Abstract:
Two dogs, with naturally acquired canine leishmaniasis, were treated orally with miltefosine (2mg/kg q 24 hr) and allopurinol
(10mg/kg q 12 hr) for 28 days. Both dogs showed good initial response to therapy, with reduction in clinical signs and improvement
of clinicopathological changes. However, in both dogs, clinical and clinicopathological abnormalities recurred 150 days after initial
treatment and a second course of miltefosine and allopurinol was administered. One dog failed to respond to the 2nd cycle of
miltefosine treatment and the other dog responded initially but suffered an early relapse. Treatment with meglumine antimoniate
(100mg/kg q 24 hr for a minimumof 4weeks)was then started in both dogs. Both dogs showed rapid clinical and clinicopathological
improvement and to date they have not received further treatment for 420 and 270 days, respectively. In view of the low number of
antileishmanial drugs available and the fact that some of these are used in human as well as veterinary medicine, it is of paramount
importance that drug resistance is monitored and documented
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
D. Proverbio, E. Spada, G. Bagnagatti De Giorgi, R. Perego
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