Preliminary In Vivo Evaluation of an Oral Multiple-Unit Formulation for Colonic Delivery of Insulin
Abstract
Data di Pubblicazione:
2014
Citazione:
Preliminary In Vivo Evaluation of an Oral Multiple-Unit Formulation for Colonic Delivery of Insulin / A. Maroni, S. Salmaso, M.D. Del Curto, G. Loreti, P. Caliceti, A. Gazzaniga - In: CRS Annual Meeting Abstracts : 2014[s.l] : Controlled Release Society, 2014 Jul. - pp. 1-2 (( Intervento presentato al 41. convegno Annual Meeting & Exposition of the Controlled Release Society tenutosi a Chicago nel 2014.
Abstract:
A multiple-unit formulation for time-dependent colonic release of insulin was prepared and evaluated. The system comprised a minitablet core containing the protein and a permeation enhancer, an internal swellable/erodible layer based on low-viscosity hydroxypropyl methylcellulose (HPMC), an intermediate Eudragit®NE film including a superdisintegrant (sodium
starch glycolate), able to slow down water penetration into the underlying functional layer, and an outermost enteric coat intended to overcome the issue of variable gastric residence. When this system was administered to diabetic rats, a peak in insulin plasma concentrations was
observed 6 h post-dose along with a drop in glycaemia. Both could coincide, based on rat gastrointestinal transit times, with the system being positioned in the ileo-colonic region.
Tipologia IRIS:
03 - Contributo in volume
Elenco autori:
A. Maroni, S. Salmaso, M.D. Del Curto, G. Loreti, P. Caliceti, A. Gazzaniga
Link alla scheda completa:
Titolo del libro:
CRS Annual Meeting Abstracts : 2014