Primary angiocentric/angioinvasive T-cell lymphoma of the tympanic bulla in a FeLV positive cat
Articolo
Data di Pubblicazione:
2014
Citazione:
Primary angiocentric/angioinvasive T-cell lymphoma of the tympanic bulla in a FeLV positive cat / S.F. Santagostino, C.M. Mortellaro, A. Forlani, G. Ghisleni, P. Roccabianca. - In: JOURNAL OF COMPARATIVE PATHOLOGY. - ISSN 0021-9975. - 150:1(2014 Jan), pp. 111-111. ((Intervento presentato al 31. convegno ESVP-ECVP Meeting tenutosi a London nel 2013 [10.1016/j.jcpa.2013.11.145].
Abstract:
Introduction: Reports of primary middle ear lymphoma are rare in
cats and their extension to internal organs is exceptional. A 5-yearold,
neutered female, FeLV-positive domestic shorthair cat was
referred for stertor, dyspnoea and head-tilt. CT scan revealed soft tissue
opacity inside the right tympanic bulla with bone lysis and concurrent
nasopharyngeal and intracranial invasion.
Materials and Methods: Endoscopic-guided biopsy samples were
collected for histology and immunohistochemistry. A full necropsy examination
was performed.
Results: Grossly, the lesion was poorly demarcated, white and soft.
Cytology identified round, large, plasmacytoid neoplastic cells. Histology
revealed dense sheets of round neoplastic cells often surrounding
or invading vascular walls (angiocentric/angiodestructive
pattern). Neoplastic cells expressed CD3 (T cell phenotype) and
FeLV p27 and gp70 antigens. A middle ear angiocentric angioinvasive
T-cell lymphoma was diagnosed. Following radiation therapy,
clinical conditions improved, but dysphagia recurred and the cat
died suddenly. At necropsy examination, a soft, red mass filled the
ventromedial compartment of the tympanic bulla. Extension to the
base of the skull with right piriform lobe compression was recorded.
Hepatic and splenic metastases were present.
Conclusions: Diagnosis of primary middle ear tumors is often delayed
since clinical signs mimic more common otological conditions.
Multiple biopsy specimens and immunohistochemistry were pivotal
for the diagnosis in this case. FeLV might have been involved in tympanic
lymphoma development.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
S.F. Santagostino, C.M. Mortellaro, A. Forlani, G. Ghisleni, P. Roccabianca
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