Data di Pubblicazione:
2014
Citazione:
Massive pulmonary alveolar lipoproteinosis in an English Bulldog / A. Forlani, C. Palmieri, S.F. Santagostino, R. Queliti, P. Roccabianca. - In: JOURNAL OF COMPARATIVE PATHOLOGY. - ISSN 0021-9975. - 150:1(2014 Jan), pp. 121-121. ((Intervento presentato al 31. convegno ESVP-ECVP Meeting tenutosi a London nel 2013 [10.1016/j.jcpa.2013.11.187].
Abstract:
Introduction: A 7-year-old, male English bulldog with a history of
juvenile idiopathic epilepsy treated with phenobarbital and bromide
developed sudden severe dyspnoea with respiratory arrest 12 h after
admission. Thoracic radiographs revealed abnormal alveolar and
interstitial patterns.
Materials and Methods: Necropsy examination was performed
and tissues were processed routinely. Sections of lung were stained
by PAS, von Kossa’s stain and Congo red. Selected lung samples
were submitted for transmission electron microscopy (TEM).
Results: There was marked hepatomegaly with a friable consistency of
the liver, mitral valve endocardiosis and pulmonary oedema with
disseminated 1e8 mm umbilicated lesions in the apical, accessory
and right principal lung lobes. Microscopically, alveoli (60e80%)
were filled with pale eosinophilic, amorphous to granular PAS-positive,
von Kossa- and Congo red-negative material associated with macrophages
and neutrophils. Interstitial fibrosis and mineralization were
moderate. Myocardial septal and right ventricle fatty infiltration was
present. TEM revealed short lamellar 3.125 nm fascicles at 6.25 nm periodic
distance and compatible with accumulation of surfactant.
Conclusions: Differentials diagnoses included alveolar proteinosis,
lipidosis and hyalinosis. The conjunction of lesions was suggestive of
alveolar lipoproteinosis/phospholipidosis. Association with mineralization
and inflammation explained the dyspnoea. The alveolar storage
could have derived from chronic administration of bromide.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
A. Forlani, C. Palmieri, S.F. Santagostino, R. Queliti, P. Roccabianca
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