Role of psoriasis as independent predictor of cardiovascular disease : a meta-regression analysis
Articolo
Data di Pubblicazione:
2013
Citazione:
Role of psoriasis as independent predictor of cardiovascular disease : a meta-regression analysis / M. Gaeta, S. Castelvecchio, C. Ricci, P. Pigatto, G. Pellissero, R. Cappato. - In: INTERNATIONAL JOURNAL OF CARDIOLOGY. - ISSN 0167-5273. - 168:3(2013 Oct 03), pp. 2282-2288. [10.1016/j.ijcard.2013.01.197]
Abstract:
Background: Despite the proved association between psoriasis and cardiovascular risk exposure, there are no data about the role of psoriasis as an independent predictor of such risk. The aim of this study was to investigate
whether any association between psoriasis and excess cardiovascular risk exposure is independent from confounding factors.
Methods: Meta-analysis and meta-regression analysis were performed using data extracted from observational
studies (identified by MEDLINE, EMBASE and CINAHL) investigating the relationship between psoriasis
and cardiovascular disease with at least 6 points on the New Castle-Ottawa quality scale. Two reviewers with
methodological expertise conducted data extraction independently.
Results: Thirteen studies including patients with psoriasis showed an increased risk of cardiovascular disease
(RR=1.24 [1.18–1.31]; P=0.0001). These patients still presented a significantly larger cardiovascular risk in the presence of smoking (RR=1.14 [CI=1.13–1.15] Pb0.0001), obesity (RR=1.11 [CI=1.07–1.14] P=
0.0003) and hyperlipidemia (RR=1.05 [CI=1.03–1.07] P=0.0006), but not in the presence of hypertension
(RR=1.03 [CI=0.98–1.09] P=0.4647) and diabetes (RR=0.95 [CI=0.90–1.01] P=0.6502).
Conclusions: Patients with psoriasis carry an about 25% increased relative risk of cardiovascular disease. This
risk appears to be independent of smoking, obesity and hyperlipidemia.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Cardiovascular diseases; Infarction; Psoriasis
Elenco autori:
M. Gaeta, S. Castelvecchio, C. Ricci, P. Pigatto, G. Pellissero, R. Cappato
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