Uptake and phosphorylation of gamma-conglutin, a hypoglycaemic lupin seed protein, by HepG2 cells
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Data di Pubblicazione:
2013
Citazione:
Uptake and phosphorylation of gamma-conglutin, a hypoglycaemic lupin seed protein, by HepG2 cells / J. Capraro. ((Intervento presentato al convegno Effost Annual Meeting : BioBased Technologies in the Context of European Food Innovation Systems tenutosi a Bologna nel 2013.
Abstract:
gamma-Conglutin, a lupin seed glycoprotein, positively influences glucose uptake in model cells and reduces glycaemia in animal models and human subjects. In particular, gamma-conglutin can activate different signaling pathways, in differentiating myocyte, that closely resembled those of insulin.
gamma-Conglutin was transcytosed through a CaCo2 cell monolayer and crossed an ex-vivo intestinal barrier in an intact form. Beside, the protein displays strong resistance to endogenous and exogenous proteolytic enzymes.
These findings encouraged us to further study the molecular mechanisms of action of this bioactive protein, which are still not completely elucidated.
Tipologia IRIS:
14 - Intervento a convegno non pubblicato
Keywords:
gamma-conglutin ; hypoglyceamic activity ; lupin
Elenco autori:
J. Capraro
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