MicroRNA and mRNA expression profile screening in multiple sclerosis patients to unravel novel pathogenic steps and identify potential biomarkers
Articolo
Data di Pubblicazione:
2012
Citazione:
MicroRNA and mRNA expression profile screening in multiple sclerosis patients to unravel novel pathogenic steps and identify potential biomarkers / F. Martinelli-Boneschi, C. Fenoglio, P. Brambilla, M. Sorosina, G. Giacalone, F. Esposito, M. Serpente, C. Cantoni, E. Ridolfi, M. Rodegher, L. Moiola, B. Colombo, M. De Riz, V. Martinelli, E. Scarpini, G. Comi, D. Galimberti. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - 508:1(2012 Feb 02), pp. 4-8.
Abstract:
Identification of novel targets and biomarkers, such as microRNAs, is extremely helpful to understand the pathogenetic mechanisms in a disease like multiple sclerosis (MS). We tested the expression profile of 1145 microRNAs in peripheral blood mononuclear cells (PBMCs) of 19 MS patients and 14 controls, and we further explored their function by performing a whole-genome mRNA profiling in same subjects and using bioinformatic prediction tool. A total of 104 miRNAs have been identified as deregulated in MS patients; 2/10 which ranked highest (let-7g and miR-150) have been validated in a replication sample, leading to the identification of putative target genes.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Adult ; Biological Markers ; Female ; Gene Expression Profiling ; Humans ; Male ; MicroRNAs ; Microarray Analysis ; Middle Aged ; Multiple Sclerosis ; RNA, Messenger
Elenco autori:
F. Martinelli-Boneschi, C. Fenoglio, P. Brambilla, M. Sorosina, G. Giacalone, F. Esposito, M. Serpente, C. Cantoni, E. Ridolfi, M. Rodegher, L. Moiola, B. Colombo, M. De Riz, V. Martinelli, E. Scarpini, G. Comi, D. Galimberti
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