Data di Pubblicazione:
2013
Citazione:
Rare fungal pathogens – upcoming guidelines:
hyalohyphomycetes / A. Tortorano, C. Lass Florl. - In: MYCOSES. - ISSN 0933-7407. - 56:Suppl. 3(2013 Oct), pp. W14.3.36-W14.3.36. (Intervento presentato al 6. convegno Trends in Medical Mycology tenutosi a COPENHAGEN nel 2013).
Abstract:
On behalf of the ECMM and EFISG Study group
Hyalohyphomycosis is a heterogeneous group of infections characterized
by the presence of hyaline hyphae in tissues. The infecting fungi,
belonging to several genera (Fusarium, Scedosporium, Acremonium,
Scopulariopsis, Purpureocillium and Paecilomyces), are ubiquitous in
the environment and commonly isolated from soil.
Histopathological findings of septate, branching, hyaline hyphae
are similar to those of aspergillosis. Therefore a definitive diagnosis
requires isolation of the pathogens from infected sites. Blood cultures
are often positive in case of invasive infection. Due to the variable
susceptibility of these fungi to antifungal agents identification of the
fungus grown on culture is important. As species identification based
on morphological characteristics is difficult, molecular identification
methods are often required. Antifungal susceptibility testing is recommended
under certain circumstances to guide antifungal therapy,
even if the clinical breakpoints have yet to be defined. Several inhouse
molecular diagnostic tests have been developed, they appear
promising but should be used only to supplement conventional laboratory
tests.
Given the lack of clinical trials, the scarcity of data and the potential
publication bias, no solid recommendations for the management
of these mycoses can be provided. Voriconazole represents the first
line treatment of infections due to Fusarium spp and Scedosporium
spp. Therapy should include surgical debridement where possible.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
A. Tortorano, C. Lass Florl
Link alla scheda completa: