Data di Pubblicazione:
2011
Citazione:
Trends in candidaemia in one Italian region, Lombardia / A.M. Tortorano, A. Prigitano, C. Ossi, A. Grancini, E. Casari, G. Viola, G. Giuliani, M. Mella, M. Longo, R. Passerini, M. Facchini, M. Tejada, M. Passera, G. Delvecchio, E. Sala, C. Sturla, A. Ceraminiello, C. Cavanna, M. Re, C. Bezzi, D. Longo, M. Arghittu, L. Re, M.R. Sala, P. Clerici, A. Grossi, P. Pedroni, G. Munafò, C. Bonetti, G. Brigante. - In: CLINICAL MICROBIOLOGY AND INFECTION. - ISSN 1198-743X. - 17:s4(2011), pp. R2641.s793-R2641.s794. (Intervento presentato al 21. convegno ECCMID/ICC tenutosi a MILANO nel 2011).
Abstract:
Objectives: To perform a 1-year survey on candidaemia in one Italian region, Lombardia, to verify
the epidemiological changes in comparison with the results of a previous survey conducted ten
years ago (Tortorano et al. J. Hosp. Infect. 2002; 51: 297).
Methods: The survey was carried out prospectively during 2009 involving 30 Microbiology
Laboratories of Lombardia that notified candidaemia episodes defined by at least one blood culture
positive for Candida.
Results: A total of 354 episodes of candidaemia occurred in 344 patients accounting for an
incidence of 1.19 per 1000 admissions (range 0.19–2.3) and 1.20 per 10000 patient days (range
0.2–2.2). These rates were higher compared to those obtained in the previous '90s survey (0.38
per 1000 admissions, range 0.03–1.45, and 0.44 per 10000 patient days, range 0.04–1.64). In the
present survey, candidaemia occurred more frequently in patients aged ?80 years (15.4 vs 8.1% of
the cases) and remained associated mainly, even if at a reduced rate, to surgery (45% of the cases
vs 56% in the previous study) and intensive care treatments (35% vs 45%). A shift of the species
causing fungaemia was demonstrated by the comparison of the two periods: while the proportion
due to C. albicans decreased from 58 to 52%, an increase of C. glabrata (from 13 to 20%) and
C. tropicalis (from 6 to 8%) was noted. The proportion of C. parapsilosis remained unchanged
(14.5%). A decreased of the crude mortality at day 30 from 35 to 32% was observed. The highest
mortality rate was detected in patients with C. tropicalis (41%) and C. albicans (33%) bloodstream
infections.
Conclusion: The present study revealed an increasing incidence of candidaemia, mainly in aged
subjects, and an increasing proportion of isolates with decreased susceptibility to fluconazole.
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Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
A.M. Tortorano, A. Prigitano, C. Ossi, A. Grancini, E. Casari, G. Viola, G. Giuliani, M. Mella, M. Longo, R. Passerini, M. Facchini, M. Tejada, M. Passera, G. Delvecchio, E. Sala, C. Sturla, A. Ceraminiello, C. Cavanna, M. Re, C. Bezzi, D. Longo, M. Arghittu, L. Re, M.R. Sala, P. Clerici, A. Grossi, P. Pedroni, G. Munafò, C. Bonetti, G. Brigante
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