Data di Pubblicazione:
1987
Citazione:
Analgesic effect of morphine: a role for beta-endorphin / A.E. Panerai, P. Sacerdote, A. Brini, P. Mantegazza. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - 74:3(1987 Mar 09), pp. 348-352.
Abstract:
Capsaicin, a neurotoxic agent that induces a decrease in hypothalamic beta-endorphin, a specific antiserum and human beta-endorphin fragment 6 31, a peptidergic beta-endorphin antagonist have been used in the attempt of selectively affecting the function of beta-endorphinergic system and of evaluating the possible role of this peptide in the analgesic effect of morphine. All 3 experimental approaches resulted in a decrease of the analgesia induced by morphine, thus suggesting that beta-endorphin is involved in the effect of morphine.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Animals; Brain; Capsaicin; Endorphins; Injections, Intraventricular; Male; Morphine; Pain; Peptide Fragments; Rats; Rats, Inbred Strains; Sensory Thresholds; beta-Endorphin
Elenco autori:
A.E. Panerai, P. Sacerdote, A. Brini, P. Mantegazza
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