Data di Pubblicazione:
1987
Citazione:
Brain and spinal cord neuropeptides in adjuvant induced arthritis in rats / A.E. Panerai, P. Sacerdote, M. Bianchi, A. Brini, P. Mantegazza. - In: LIFE SCIENCES. - ISSN 0024-3205. - 41:10(1987 Sep 07), pp. 1297-1303. [10.1016/0024-3205(87)90209-8]
Abstract:
The concentrations of brain and spinal cord beta-endorphin, met-enkephalin, dynorphin and substance P were measured in rats bearing the Freund adjuvant induced arthritis. Beta-endorphin brain concentrations decreased gradually in time with a nadir on day twenty-one, when arthritis was at its maximum, and were back to normal by day thirty-five, when arthritis was no more evident. Met-enkephalin concentrations increased in brain areas and in the lumbar spinal cord and returned to normal with the same time pattern, while dynorphin and substance P concentrations did not change. These data indicate that peripheral lesions can induce important changes in brain concentrations of some opioid peptides involved in the modulation of pain.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Animals ; Arthritis ; Arthritis, Experimental ; Brain ; Dynorphins ; Endorphins ; Enkephalin, Methionine ; Male ; Neuropeptides ; Rats ; Rats, Inbred Strains ; Spinal Cord ; Substance P ; Time Factors ; Tissue Distribution ; beta-Endorphin
Elenco autori:
A.E. Panerai, P. Sacerdote, M. Bianchi, A. Brini, P. Mantegazza
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