Data di Pubblicazione:
2013
Citazione:
Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease / A.M. Barron, L.M. Garcia-Segura, D. Caruso, A. Jayraman, J.W. Lee, R.C. Melcangi, C.J. Pike. - In: THE JOURNAL OF NEUROSCIENCE. - ISSN 0270-6474. - 33:20(2013 May 15), pp. 8891-8897.
Abstract:
Ligands of the translocator protein (TSPO) elicit pleiotropic neuroprotective effects that represent emerging treatment strategies for several neurodegenerative conditions. To investigate the potential of TSPO as a therapeutic target for Alzheimer's disease (AD), the current study assessed the effects of the TSPO ligand Ro5-4864 on the development of neuropathology in 3xTgAD mice. The effects of the TSPO ligand on neurosteroidogenesis and AD-related neuropathology, including β-amyloid accumulation, gliosis, and behavioral impairment, were examined under both early intervention (7-month-old young-adult male mice with low pathology) and treatment (24- month-old, aged male mice with advanced neuropathology) conditions. Ro5-4864 treatment not only effectively attenuated development of neuropathology and behavioral impairment in young-adult mice but also reversed these indices in aged 3xTgAD mice. Reduced levels of soluble β-amyloid were also observed by the combination of TSPO ligands Ro5-4864 and PK11195 in nontransgenicmice.ThesefindingssuggestthatTSPOisapromisingtargetforthedevelopmentofpleiotropictreatmentstrategies for the management of AD.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Alzheimer Disease ; Amyloid beta-Peptides ; Amyloid beta-Protein Precursor ; Animals ; Benzodiazepinones ; Disease Models, Animal ; Humans; Isoquinolines ; Male ; Maze Learning ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Orchiectomy ; Presenilin-1 ; Receptors, GABA ; Steroids ; tau Proteins
Elenco autori:
A.M. Barron, L.M. Garcia-Segura, D. Caruso, A. Jayraman, J.W. Lee, R.C. Melcangi, C.J. Pike
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