Diagnostic value of faecal calprotectin in unselected outpatients referred for colonoscopy : A multicenter prospective study
Articolo
Data di Pubblicazione:
2010
Citazione:
Diagnostic value of faecal calprotectin in unselected outpatients referred for colonoscopy : A multicenter prospective study / G. Meucci, R. D'Incà, R. Maieron, N. Orzes, M. Vecchi, D. Visentini, G. Minoli, E. Dal Pont, M. Zilli, E. Benedetti, T. Virgilio, E. Tonutti. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - 42:3(2010 Mar), pp. 191-195.
Abstract:
Objectives: To evaluate the role of faecal calprotectin in consecutive outpatients referred for colonoscopy. Methods: Outpatients undergoing colonoscopy at five participating institutions were eligible. Demographic and clinical data were collected. Faecal samples were tested at a single laboratory by means of a commercially available kit. Results: We consecutively enrolled 870 patients. Mean levels of calprotectin were significantly higher in patients with neoplastic and inflammatory disorders when compared with subjects with a normal colonoscopy or trivial endoscopic findings. Elevated calprotectin levels (>50 mg/dl) were detected in 85% of patients with colorectal cancer, and 81% of those with inflammatory conditions but also in 37% of patients with normal or trivial endoscopic findings. In patients referred for chronic diarrhoea, sensitivity and negative predictive value were 100% in detecting either any organic colonic disease. In patients referred for symptoms of "suspected functional origin" sensitivity and negative predictive value for colorectal cancer were also 100%. Conclusions: In unselected outpatients referred for colonoscopy, a single measurement of faecal calprotectin is not sufficiently accurate to identify those with significant colorectal disease. However, a normal result can help rule out organic disease among patients with diarrhoea and those with abdominal pain and/or constipation.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Abdominal Pain ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological Markers ; Colonic Polyps ; Colonoscopy ; Colorectal Neoplasms ; Constipation ; Diarrhea ; Feces ; Female ; Gastroenteritis ; Humans ; Leukocyte L1 Antigen Complex ; Male ; Middle Aged ; Outpatients ; Predictive Value of Tests ; Prospective Studies ; Young Adult
Elenco autori:
G. Meucci, R. D'Incà, R. Maieron, N. Orzes, M. Vecchi, D. Visentini, G. Minoli, E. Dal Pont, M. Zilli, E. Benedetti, T. Virgilio, E. Tonutti
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